Klf6 endothelial
WebThese results suggest that KLF6 regulates MMP14 transcription and is a critical player of the gene expression network triggered during endothelial repair. Keywords: Endothelial cells; KLF6; MMP14; Soluble endoglin; Transcription; Vascular injury. WebSep 24, 2013 · KLF6-SV1 knockdown also reduces the expression of angiogenesis-related proteins such as vascular endothelial growth factor in xenograft models of prostate and gastric cancers 58,159. KLFs and ...
Klf6 endothelial
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WebFeb 1, 2024 · Although, a role for KLFs in kidney diseases are identified, significant gaps exist in understanding role of KLF5, KLF6, and KLF15 in glomerular endothelial cells, role of KLF10 and KLF11 in kidney fibrosis, and determining gender specific differences in … WebFeb 6, 2024 · Non-coding RNAs (ncRNAs) play a pivotal role in regulating the tumor microenvironment (TME) by controlling gene expression at multiple levels. In tumors, ncRNAs can mediate the crosstalk between cancer cells and other cells in the TME, such as immune cells, stromal cells, and endothelial cells, influencing tumor development and …
WebJan 2, 2024 · PDFPRINTCPT Code: 81479 Order Code: 1350 ABN Requirement: No Specimen: EDTA Whole Blood Volume: 4.0 mL Minimum Volume: 2.0 mL Container: EDTA (Lavender Top) tube Collection: Collect and label sample according to standard protocols. … WebSep 8, 2024 · Recently, KLF6 was reported to regulate the expression of CAMs and mediate adhesion between endothelial cells and monocytes [21, 40]. In this study, we found that KLF6 was dramatically downregulated in histamine-treated hNECs but elevated by febuxostat, which is consistent with previous reports [ 21 ].
WebTherefore, KLF6 in endothelial cells can promote the in ltration of immune cells during vascular injury [15]. However, the role of KLF6 and iNOS in PA supernatant induced macrophage apoptosis is ... WebFurthermore, KLF6 markedly increases the transcriptional activity of different reporter constructs of MMP14 gene promoter. These results suggest that KLF6 regulates MMP14 transcription and is a critical player of the gene expression network triggered during …
WebApr 2, 2013 · We found that KLF6 and MEF2D are co-localized in the nuclei of mononucleated but not multinucleated myogenic cells and, that the MEF2 cis element is a key component of the KLF6 promoter region. ... Transcriptional activation of urokinase by the Krüppel-like factor Zf9/COPEB activates latent TGF-beta1 in vascular endothelial cells. …
WebFeb 5, 2016 · After endothelial injury, the transcription factor Krüppel-like factor 6 (KLF6) translocates into the cell nucleus to regulate a variety of target genes involved in angiogenesis, vascular repair and remodeling, including components of the membrane transforming growth factor beta (TGF-β) receptor complex such as endoglin and activin … flights from luxembourg to baliWebJul 1, 2005 · We previously showed that KLF6, a ubiquitously expressed zinc finger transcription factor, is a tumor suppressor gene inactivated by allelic loss and somatic mutation in sporadic prostate cancers that can mediate growth suppression both by a p53-independent, up-regulation of p21 ( 2 ), and by disrupting the interaction between cyclin … flights from luxembourg to bakuWebA mouse cDNA encoding a zinc finger protein, called Klf6, which is a member of the Krüppel-like family of transcription factors, has been cloned. Northern blot analyses showed that Klf6 was already expressed in 11.5-d postconception mouse embryos and that its expression … flights from luton to zurich directWebHere, we aim to explore the function and mechanism of LOXL1-AS1 in modulating oxidized low-density lipoprotein (ox-LDL)-induced angiogenesis of endothelial cells (ECs). Presently, we found that LOXL1-AS1 and KLF6 were upregulated in ECs treated by Ox-LDL in a dose- and time-dependent manner while miR-590-5p was downregulated. cherokee bible church cherokee ncWebMar 21, 2024 · GeneCards Summary for KLF6 Gene. KLF6 (KLF Transcription Factor 6) is a Protein Coding gene. Diseases associated with KLF6 include Prostate Cancer and Gastric Cancer . Among its related pathways are Aryl hydrocarbon receptor pathway and … flights from luxembourg to hanoiWebMay 18, 2024 · Under different stress conditions, the loss of specific KLF members (including KLF2, KLF4, KLF6, and KLF15) in glomerular endothelial cells or podocytes will lead to the aggravation of renal injury. KLF2 has anti-inflammatory effects in endothelial cells, thus protecting cells from cell stress damage and slowing the progression of … cherokee bend moundville alWeb虽然已提出了许多假说，但目前PAH进展的具体调控机制仍不明确。近来研究表明，慢性缺氧是PAH患者血管重构的重要刺激因素[2，3]，低氧诱导的肺动脉内皮细胞（pulmonary artery endothelial cell，PAEC）损伤在PAH的血管重构中发挥重大作用[4，5]。 cherokee bible