Mafb transcription factor
WebMay 7, 2024 · MAFB:MAF bZIP transcription factor B [Gene - OMIM - HGNC] Variant type: single nucleotide variant Cytogenetic location: 20q12 Genomic location: ... The MAFB c.212C>T (p.Pro71Leu) variant is a missense variant and has been reported in at least two individuals in a de novo heterozygous state. Both individuals presented with skeletal … WebTranscription Factor MafB. The transcription factors MafB and c-Maf belong to a family of basic-leucine zipper (b-Zip) factors that bind DNA as dimers. From: Hematology (Seventh …
Mafb transcription factor
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WebSep 26, 2024 · MAFB is an important transcription factor involved in lymphangiogenesis. Study provides insights to elucidate mechanisms of gene regulation through androgen response elements present in Mafb 3'UTR for a better understanding of the processes of urethral masculinization. WebApr 28, 2024 · The transcription factor, MafB, plays important role in the differentiation and functional maintenance of various cells and tissues, …
WebMar 22, 2016 · MafB, a transcription factor expressed selectively in macrophages, has important roles in some macrophage-related diseases, especially in atherosclerosis. In this study, we investigated the mechanism by which hematopoietic-specific MafB deficiency induces the development of obesity. WebNov 18, 2024 · Based on these hallmarks, and considering the pivotal role of macrophages in COVID-19 pathogenesis, we hypothesize that the transcription factors MAFB and MAF …
WebJul 1, 2002 · This work has shown that Maf proteins contain a highly conserved acidic transactivation domain (AD), and a bZIP region that mediates DNA‐binding activity, which plays key roles in vertebrate lens development. Background: Members of the Maf family, including L‐Maf, MafB and c‐Maf, are ‘basic region/leucine zipper’ (bZIP) transcription … WebJul 1, 2013 · MAFB was equally responsive to H 2 O 2 in βTC-3 cells (Figure 2 E), with C-terminal sequences spanning the conserved MAFA and MAFB DNA-binding/dimerization domain sufficiently to mediate nuclear-to-cytoplasmic translocation (see myc-MAFA [210–323] and myc-MAFB [210–323] in Supplemental Figure 1A).
WebMay 15, 2014 · The large Maf transcription factors, MafA and MafB, are expressed with distinct spatial–temporal patterns in rodent islet cells. Analysis of Mafa−/− and pancreas-specific Mafa∆panc deletion mutant mice demonstrated a primary role for MafA in adult β-cell activity, different from the embryonic importance of MafB.
WebMaf transcription factors are a family of basic-leucine zipper transcription factors that are closely related to V-MAF ONCOGENE PROTEIN. maven 3.8.5 download for windows 10WebMar 14, 2024 · MAFB, MAF bZIP transcription factor B Vertebrate Orthologs 3 Human Diseases more Diseases 2 with Mafb mouse models; 2 with human MAFB associations Mutations, Alleles, and Phenotypes less Phenotype Summary 75 phenotypes from 11 alleles in 12 genetic backgrounds 4 phenotypes from multigenic genotypes herlittlewolves.comWebApr 4, 2024 · Gene ID: 9935, updated on 19-Feb-2024. Summary. The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that plays an important role in … maven 4.0 releaseWebNov 11, 2024 · Interferon regulatory factor 8 (IRF8) and v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B (MafB), known as the negative osteoclast transcription factors, suppress the transcriptional activity of NFATc1 [24,25]. herlittlesecret攻略WebA second transcription factor, MafB (also called Kreisler after the mouse bearing a mutation in this gene), is expressed in the podocyte beginning in the capillary loop stage (around E14.5) and extending into adulthood ( Sadl et al 2002 ). Mice homozygous for a genetic mutation in MafB exhibit developmental defects in the hindbrain and kidney. her little secret v0.2.3WebMafB (transcriptional activator v-maf musculoaponeurotic fibrosarcoma oncogene homologue B) is a basic leucine zipper transcription factor expressed in the developing parathyroid after E11.5 and postnatally. MafB expression is lost in the parathyroid primordium of gcm2 null mice. herlittleword.frher little wolves