T-2 toxin solubility
WebSep 10, 2024 · T-2 toxin is the most toxic trichothecene mycotoxin, and it exerts potent toxic effects, including immunotoxicity, neurotoxicity, and reproductive toxicity. Recently, several novel metabolites, including 3′,4′-dihydroxy-T-2 toxin … WebApr 27, 2011 · Among the naturally occurring trichothecenes in food and feed, T-2 toxin is a cytotoxic fungal secondary metabolite produced by various species of Fusarium. Following ingestion, T-2 toxin causes acute and chronic toxicity and induces apoptosis in the immune system and fetal tissues.
T-2 toxin solubility
Did you know?
WebMay 3, 2012 · Abstract. The mycotoxin T-2 toxin, produced by various Fusarium species, is a widespread contaminant of grain and grain products. Knowledge about its toxicity and metabolism in the human body is ... WebThe T-2 toxin (T-2) is a type A trichothecene produced by Fusarium species, and the most cytotoxic mycotoxin of the group. A study was made to determine T-2 cytotoxicity in human hepatocarcinoma (HepG2) cells; evaluate whether there is an adaptive response of HepG2 cells exposed to low concentrations of T-2; identify the T-2 metabolites by LC-Q-TOF MS; …
WebNov 14, 2024 · The half-life of T-2 in plasma is short, and elimination is usually completed within 48 h, depending on the administration mode, the consumed amount, and on species-specific differences [ 44 ]. In addition, toxin does not accumulate in significant quantity in various organs such as the kidneys, liver, or the skeletal muscle [ 45, 46 ]. http://www.biotechrep.ir/article_68941_56d33ed14a114b64f7195cdcf1c68c27.pdf
WebMay 5, 2024 · T-2 toxin exposure results in leukopenia and cell depletion in lymphoid organs. It also inhibits erythropoiesis in the bone marrow and spleen and significantly impairs antibody production, reducing the proliferative response of lymphocytes and hindering the development of dendritic cells . The T-2 toxin is also reported to inhibit IL-2 … WebT-2 toxin is a trichothecene mycotoxin that has been found in Fusarium. 1 It binds to and inhibits peptidyltransferase in the 60S ribosomal subunit, inducing a ribotoxic stress response that triggers JNK and p38 MAPK signaling. T-2 toxin (3 nM) decreases toll-like receptor expression and LPS-induced production of IL-1β, TNF-α, and nitric ...
WebThe T-2 toxin (T-2) is a type A trichothecene produced by Fusarium species, and the most cytotoxic mycotoxin of the group. A study was made to determine T-2 cytotoxicity in human hepatocarcinoma (HepG2) cells; evaluate whether there is an adaptive response of HepG2 cells exposed to low concentration ….
WebT-2 mycotoxins alter cell membrane structure and function, inhibits mitochondrial respiration, and inactivates certain enzymes. Symptoms of T-2 mycotoxicosis are usually observed within two to four hours, but significant exposure can cause onset of symptoms in minutes. T-2 mycotoxicosis symptoms will vary cheapest 5 year fix mortgageWebT2-Toxin solution 100 μg/mL in acetonitrile, analytical standard Synonym (s): Epoxytrichothecene, Fusariotoxin T 2, Mycotoxin T 2 Empirical Formula (Hill Notation): C24H34O9 CAS Number: 21259-20-1 Molecular Weight: 466.52 EC Number: 200-835-2 MDL number: MFCD00871255 PubChem Substance ID: 329754792 NACRES: NA.24 cheapest 5 year fixed mortgage ratesT-2 Mycotoxin (pronounced as 'Tee-Two') is a trichothecene mycotoxin. It is a naturally occurring mold byproduct of Fusarium spp. fungus which is toxic to humans and animals. The clinical condition it causes is alimentary toxic aleukia and a host of symptoms related to organs as diverse as the skin, airway, and … See more Alimentary toxic aleukia (ATA), a disease which is caused by trichothecenes like T-2 mycotoxin, killed many thousands of USSR citizens in the Orenburg District in the 1940s. It was reported that the mortality rate was 10% of the … See more The toxicity of T-2 toxin is due to its 12,13-epoxy ring. Epoxides are in general toxic compounds; these react with nucleophiles and then undergo … See more ADME Properties Absorption & Exposure Humans and animals are generally exposed to T-2 mycotoxins through food. Certain grains can contain the toxin which makes it a threat to human health and an economic burden. … See more There are currently no applications, aside from war, for T-2 mycotoxins; however, there are some plausible therapeutic uses. Due to their abilities, … See more This compound has a tetracyclic sesquiterpenoid 12,13-epoxytrichothene ring system, which relates it to the trichothecenes. These compounds are generally very stable and are not degraded during storage/milling and cooking/processing … See more T-2 mycotoxin is produced naturally by Fusarium fungi of which the most important species are: F. sporotrichioides, F. langsethiae, F. acuminatum and F. poae. These fungi are … See more At the moment, there is no specific therapy for T-2 mycotoxin poisonings. Exposure of the mycotoxin is typically followed by standardized treatment for toxic compounds in … See more cheapest 60 inch lcd tvWebT-2 mycotoxin C24H34O9 CID 6711181 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. cheapest 5 year mortgage ratesWebtrichothecenes are classified into A, B, C, and D groups. T-2 toxin, a member of the A-group trichothecenes, is the most poisonous trichothecene (10 folds more poisonous than B-group trichothecenes like deoxynivalenol). Chemi-cally, T-2 toxin is insoluble in water but soluble in ace-tone, ethyl acetate, chloroform, ethanol, methanol and pro- cva heart institute abingdon va fax numberWebJan 1, 2014 · Since the solubility of T2T, like that of most other mycotoxins, in water is very low, water organic mixtures are used as extract ants; a 70 : 30 ... T-2 toxin (group II) led to an increase in the ... cva heart institute elizabethtonWebDec 17, 2024 · T-2 toxin is a trichothecene mycotoxin commonly found in animal feed and agricultural products. Evidence indicates that T-2 toxin induces apoptosis and autophagy. This study investigated the role of ferroptosis in T-2 toxin cytotoxicity. RAS-selective lethal compound 3 (RSL3) and Erastin were applied to initiate ferroptosis. RSL3- and Erastin … cheapest 5 year loan