Trim37 function
WebJan 25, 2024 · TRIM37 is a RING-B-box-coiled-coil protein with E3 ubiquitin ligase activity ( Kallijärvi et al., 2005; Kallijärvi et al., 2002 ), which somehow prevents the formation of foci … WebThe TRIM37 (also known as MUL) gene is located in the 17q23 chromosomal region, which is amplified in up to ~40% of breast cancers1. TRIM37 contains a RING finger domain, a hallmark of E3 ...
Trim37 function
Did you know?
WebAug 21, 2024 · TRIM37 depletion increases basal autophagic flux. To explore how cells respond to the stresses caused by the loss of TRIM37 functions, we examined the … WebThe molecular role played by TRIM37 in such loss and gain of function conditions has been a focus of research in the last decade, which led notably to the identification of critical …
WebA key function of TRIM37 is to prevent the formation of ectopic centrosomal protein assemblies that acquire the ability to serve as MTOCs. In acentrosomal cells generated by centrinone treatment, TRIM37 loss enables the formation of an array of PLK4-scaffolded foci that recruit centrosomal proteins and serve as MTOCs that substitute for … WebPrimary Ovarian Insufficiency. Watchlist. (log in to enable)
WebFeb 26, 2024 · The absence of the TRIM37 protein induces the formation of ... The scientific literature shows that development of this disease is associated with the lack of function of a gene known as TRIM37. WebThe present invention is related to a method for detecting and identifying protein-protein or protein-small molecule interactions using a bait and prey system. It is also related to bait and prey proteins, small molecules and constructs that are …
WebApr 11, 2024 · During chronic hepatitis B virus (HBV) infection, hepatic fibrosis is a serious pathological condition caused by virus-induced liver damage. The activation of hepatic stellate cells (HSCs) is a central event in the occurrence and progression of liver fibrosis. Although accumulating evidence has shown that HBV directly stimulates HSC activation, …
Web본 발명은 iPS 세포 유도인자를 인코딩하는 단일 가닥 mRNA를 포함하는 정제된 RNA 제제를 사용하여 체세포를 리프로그래밍하기 위한 조성물 및 방법을 제공한다. 상기 정제된 RNA 제제는 바람직하게는 RNA 오염물질 분자가 실질적으로 없으며, 이는 i) 체세포에서 면역반응을 활성화시킬 수 있고, ii ... tapo tc60 reviewWebJul 1, 2024 · As a transcription factor, p53 functions as a homotetramer and binds to the p53-responsive elements in p53 target genes to transcribe these genes in cells. 12, 13 The p53-responsive element is composed of two decamers separated by a spacer of 0–14 nucleotides: RRRCWWGYYY (spacer) RRRCWWGYYY, where R is a purine, W is A or T, and … tapo smart light bulbsWebOct 13, 2024 · TRIMs play vital roles in immune regulation and development and the changes in the function/expression of TRIM proteins which are associated with cancer. ... tapo view on pcWebBCL6 function is also impaired by acetylation, which triggers BCL6 dissociation from corepressor complexes (Bereshchenko et al., 2002). Interestingly, acetylation has a negative effect on BCL6 activity while it positively affects the function of TP53, one of the well-characterized BCL6 targets, suggesting a coordinated action between functional silencing … tapo webcam loginWebSep 13, 2024 · Generally, TRIM proteins function as E3 ligases to facilitate specific proteasomal degradation of target proteins. In addition, E3 ligase independent functions of TRIM protein were also reported. In hepatocellular carcinoma, ... TRIM37 activates the AKT pathway to induce sorafenib resistance . tapo watch onlineWebSep 9, 2024 · Fig. 1: TRIM37 levels determine mitotic outcomes and cancer-specific sensitivity to PLK4 inhibition. a, Still images from time lapse sequences showing … tapo warrantyWebSep 22, 2015 · Increasing evidence indicated that tripartite motif containing 37 (TRIM37) was involved in the tumorigenesis of several cancer types. However, its expression pattern and biological functions in pancreatic ductal adenocarcinoma (PDAC) remained unknown. In this study, real-time PCR, Western blot and immunohistochemistry was performed to … tapo web access